Recommendation for Altage Omega 3
A number of observational studies and a small number of randomized trials have reported that higher intakes of fish or long-chain (LC) omega-3 fatty acids from dietary supplements reduce the risk for depression, heart disease, arthritis, and macular degeneration. Some evidence suggests that omega-3 fatty acids may also help prevent prostate cancer and reduce the frequency of seizures in people with epilepsy. However, the evidence for most of these benefits is inconsistent or limited and some data are contradictory.
The Dietary Guidelines for Americans and the American Heart Association recommend one to two servings of seafood per week, especially fatty fish, to reduce the risk for heart disease. A recent clinical trial, called REDUCE-IT, found that consuming 1 g/day EPA plus DHA from a fish oil supplement reduced the risk for serious vascular events (composite of nonfatal myocardial infarction or stroke, transient ischemic attack, and cardiovascular death) by 19%, compared to placebo. The AHA recommends that the EPA and DHA in your diet come from seafood, especially oily fish, and that supplements should be used only under the direction of a health care professional.
Observational studies have reported that higher fish consumption is associated with lower rates of dementia and Alzheimer’s disease. The Rotterdam Study and a nested cohort study within the AREDS study, showed that individuals with the highest LC omega-3 dietary intakes had about a 50% lower risk for the development of dementia or Alzheimer’s disease. A 2020 Cochrane review of 86 randomized controlled trials of LC omega-3 supplements in a population with high cholesterol found that the use of LC omega-3 supplements reduced serum triglyceride levels and slightly decreased coronary heart disease and cardiovascular mortality but did not significantly affect all-cause death or cardiovascular event rates [66]. A small number of randomized clinical trials in people with rheumatoid arthritis and other inflammatory conditions have shown that omega-3 fatty acid supplementation decreases inflammation and improves symptoms and physical function.